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Ginseng modulates the immune response by induction of interleukin-12 production

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Larsen MW, Moser C, Høiby N, Song Z, Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS 112;2004:369–73.

In infections with intracellular microorganisms such as mycobacteria and Leishmania parasites as well as certain extracellular chronic infections such as Pseudomonas aeruginosa a Th1 response with activation of macrophages is desirable. Several studies indicate that such a response is associated with better recovery from infection, improved course of the chronic infection, and higher survival rate. In Th1 responses there is increased interferon-γ (IFN-γ) and interleukin-12 (IL-12) production, whereas that of interleukin-10 (IL-10) is decreased. The present study indicated that Ginseng modulation of stimulated peripheral blood mononuclear cells (PBMC) results in a higher IL-12 production. The enhanced IL-12 production could induce a stronger Th1 response, resulting in better protection against infection with a variety of pathogens.
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Keywords: Ginseng; Th1; interferon-γ; interleukin-10; interleukin-12

Document Type: Research Article

Affiliations: Department of Clinical Microbiology, University Hospital (Rigshospitalet), afsnit 7602, Copenhagen, Denmark

Publication date: June 1, 2004

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