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A rare course of Whipple's disease with atypical cardiac manifestation: Case report

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Gunia S, Behrens MH, Stosiek P. A rare course of Whipple's disease with atypical cardiac manifestation. APMIS 2004;112:222–4.

Whipple's disease (WD) is a rare disorder caused by the gram-positive actinomycete Tropheryma whippelii (1). An oral route of acquisition is presumed (2). WD is a chronic systemic infection morphologically characterized by foamy PAS-positive macrophages. This case report depicts the diagnosis and clinical management of a woman who presented with atypical cardial manifestations of WD and died from severe cardiac impairment by Tropheryma whippelii which was confirmed by polymerase chain reaction. Histological assessment of myocardial specimens obtained at autopsy showed PAS-positive macrophages accumulating within foci of interstitial myocardial fibrosis. Immunohistochemical staining demonstrated myocarditis with lymphocytes and neutrophilic granulocytes, which has not been reported so far in the course of WD.
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Keywords: Myocarditis; Tropheryma whippelii; myocardial fibrosis

Document Type: Research Article

Affiliations: 1: Pharmazentrum, Universitätsklinik Frankfurt/Main, Germany 2: Institut für Pathologie, Carl-Thiem-Klinikum, Cottbus, Germany

Publication date: March 1, 2004

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