Skip to main content
padlock icon - secure page this page is secure

The regulation of rhinovirus infection in vitro by IL-8, HuIFN-α, and TNF-α

Buy Article:

$52.00 + tax (Refund Policy)

Berg K, Andersen H, Owen TC. The regulation of rhinovirus infection in vitro by IL-8, HuIFN-α, and TNF-α. APMIS 2004;112:172–82.

The influence of three important cytokines (IL-8, TNF-α, and HuIFN-α) on ongoing rhinovirus infections has been examined in vitro, individually or as combinations. TNF-α was able to transform traces of HRV infections into full-blown infections. Furthermore, TNF-α was able to down-regulate the antiviral action of HuIFN-α completely, even at levels of just a few pg/ml. This suggests that the induction of TNF-α by HRV may be part of the virus's strategy to minimize the interferon response which is part of the host's immune defence system. However, troxerutin (a flavonoid) was able to neutralize the downregulatory action of TNF-α on the HuIFN-α system at low levels and re-establish the antiviral activity ascribed to IFN-α. IL-8 exerted a minor influence on the interferon system, and had no influence on rhinovirus infections. The in vitro findings are supported, in part, by recent in vivo findings in a common cold pilot study.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: HuIFN-α; IL-8; Rhinovirus; TNF-α; allergic rhinitis; common cold; in vitro; troxerutin

Document Type: Research Article

Affiliations: 1: The Interferon Laboratory, The Panum Institute, IMMI, University of Copenhagen, Denmark 2: University of South Florida, Dept. of Chemistry, USA

Publication date: March 1, 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more