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The role of dendritic cells in the pathogenesis of HIV-1 infection

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Loré K, Larsson M. The role of dendritic cells in the pathogenesis of HIV-1 infection. APMIS 2003;111:776–88.

Dendritic cells are professional antigen-presenting cells required for generation of adaptive immunity. These cells are one of the initial target cells for HIV-1 infection or capture of virions at site of transmission in the mucosa. DCs carrying HIV-1 will migrate to the lymphoid tissue where they can contribute to the dissemination of the virus to adjacent CD4+ T cells. In addition, HIV-1–exposed DCs may have impaired antigen-presenting capacity resulting in inadequate expansion of HIV-1–specific T cell responses. Here, we review the infection of different subtypes of DCs by HIV-1 and the relevance of these cells in the transmission and establishment of HIV-1 disease. In addition, we discuss the mechanisms through which HIV-1–DC interactions could be exploited to optimise the generation and maintenance of HIV-1–specific T cell immunity.
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Keywords: Dendritic cells; HIV-1 infection; adaptive immunity; pathogenesis

Document Type: Research Article

Affiliations: The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, USA

Publication date: July 1, 2003

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