Skip to main content
padlock icon - secure page this page is secure

Phenotype and function of rat dendritic cell subsets

Buy Article:

$52.00 + tax (Refund Policy)

Yrlid U, MacPherson G. Phenotype and function of rat dendritic cell subsets. APMIS 2003;111:756–65.

Dendritic cells (DC) comprise phenotypically-distinct subsets that sub-serve distinct functions in immune induction. Understanding the biology of DC subsets in vivo is crucial for the understanding of immune regulation and its perturbations in disease. This review focuses on the phenotype and functions of rat DC subsets and compares these with subsets identified in other species. Our research has concentrated on DC migrating in lymph. DC migrate constitutively from peripheral tissues to draining nodes, probably to induce/maintain tolerance to self- or harmless foreign antigens. After removal of mesenteric lymph nodes (MLN) in the rat, healing of afferent and efferent lymphatics permits migrating intestinal DC (iLDC) to be collected from the thoracic duct. We have shown that iLDC consist of least two subsets that differ in phenotype, in situ distribution and function. CD4+/SIRPα+ iLDC are highly immunostimulatory, but are excluded from T cell areas of MLN. In contrast, CD4/SIRPα iLDC are less potent stimulators of T cells, but carry material from apoptotic enterocytes to T cell areas of MLN. Similar subsets exist in both lymph nodes and spleen. It has been shown that phenotypically-similar subsets migrate in skin-draining lymph in cattle and sheep. We and others have shown that splenic CD4/SIRPα DC can phagocytose allogeneic cells in vitro, are poor stimulators of CD8+ T cells, and can lyse NK-sensitive target cells. Although some of our data suggest that rat CD4/SIRPα DC may equate to murine CD8+ DC, there is at present insufficient evidence to be confident of this.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Dendritic cell; lymph; migration; rat; subsets; tolerance

Document Type: Research Article

Affiliations: Sir William Dunn School of Pathology, University of Oxford, United Kingdom

Publication date: July 1, 2003

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more