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Dendritic cells as inducers of antimicrobial immunity in vivo

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Sundquist M, Johansson C, Wick MJ. Dendritic cells as inducers of antimicrobial immunity in vivo. APMIS 2003;111:715–24.

Models of infection have provided important insight into the function of dendritic cells (DC) in vivo. Several microbial products induce DC maturation via Toll-like receptors, a process that is crucial for the ability of DC to initiate adaptive immune responses. Splenic DC have also been shown to produce IL-12 during infection in vivo. This DC-derived IL-12 might be important to skew T cell responses towards Th1. Microbial infections also induce changes in the DC populations of lymphoid organs, often in a subset-specific manner, manifested as an accumulation and redistribution of DC. Furthermore, data are emerging pointing at an absolute requirement of DC in priming of naïve T cells in vivo.
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Keywords: Dendritic cells; IL-12; Leishmania; Listeria; Salmonella; T cell priming; Toll-like receptors

Document Type: Research Article

Affiliations: Department of Clinical Immunology, Göteborg University, Sweden

Publication date: July 1, 2003

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