Skip to main content
padlock icon - secure page this page is secure

Free Content Liver Transplantation Using Chagas‐Infected Donors in Uninfected Recipients: A Single‐Center Experience Without Prophylactic Therapy

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Organ shortage is the first cause of death on liver transplant waiting lists. As a consequence, we recently decided to expand liver acceptance to those organs that could potentially transmit infectious diseases to their recipients. On January 2010, we initiated a prospective protocol using livers from Chagas‐infected donors for transplanting uninfected recipients without using prophylactic therapy. During a 13‐month period, 9 of 37 (24%) liver transplants were performed within this protocol. After transplant, each recipient was sequentially and strictly monitored for infection transmission using the Strout method and promptly treated with benznidazole if this occurs. During follow‐up, two patients died without Chagas infection and only two (donor‐derived T. cruzi transmission rate: 2/9; 22%) patients developed donor‐derived Chagas transmission without clinical symptoms. The median follow‐up time of the seven live patients was 15 months (range: 13–20). At present, all are symptoms‐free with excellent allograft function and without evidence of Chagas disease. In conclusion, we consider that Chagas‐infected donors are a promising source of liver grafts that could reduce the growing mortality on liver waiting lists in America. Relevant data from larger prospective studies are required to confirm these preliminary excellent results.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: October 1, 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more