this page is secure
Very Early Recurrence of Anti‐Phospholipase A2 Receptor‐Positive Membranous Nephropathy After Transplantation
Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti‐Phospholipase A2 receptor autoantibodies. We describe a 63‐year‐old man with membranous nephropathy
who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co‐localization of Phospholipase A2 receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti‐Phospholipase A2
receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A2 receptor‐associated recurrent membranous nephropathy with circulating anti‐Phospholipase A2
receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics
Document Type: Research Article
Affiliations: 1: Department of Medicine, University of Iowa and Iowa City VA Medical Center, Iowa City, IA 2: Department of Medicine, Boston University Medical Center, Boston, MA 3: Department of Pathology, University of Iowa, Iowa City, IA
Publication date: June 1, 2012
Receive new issue alert