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Free Content Very Early Recurrence of Anti‐Phospholipase A2 Receptor‐Positive Membranous Nephropathy After Transplantation

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Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti‐Phospholipase A2 receptor autoantibodies. We describe a 63‐year‐old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co‐localization of Phospholipase A2 receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti‐Phospholipase A2 receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A2 receptor‐associated recurrent membranous nephropathy with circulating anti‐Phospholipase A2 receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.
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Document Type: Research Article

Affiliations: 1: Department of Medicine, University of Iowa and Iowa City VA Medical Center, Iowa City, IA 2: Department of Medicine, Boston University Medical Center, Boston, MA 3: Department of Pathology, University of Iowa, Iowa City, IA

Publication date: June 1, 2012

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