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Open Access Effect of Cumulative Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in Patients with Atypical Parkinsonism: A Pilot Study

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Objective: To investigate the potential of cumulative high-frequency repetitive transcranial magnetic stimulation (HFrTMS) on freezing of gait in atypical Parkinsonism.

Design: Randomized, single-blinded, crossover study with a blinded observer.

Participants: Eight patients with atypical Parkinsonism.

Methods: All participants received HF-rTMS over the lower leg primary motor cortex (M1-LL) for 5 consecutive days. Alternative sham stimulation was also administered with a 2-week wash-out period. Freezing of Gait Questionnaire (FOG-Q), turn steps in the modified Standing Start 180° Turn Test, the Timed Up and Go (TUG) task, and the Unified Parkinson's Disease Rating Scale part III (UPDRS-III) were performed before, after, and one week after rTMS.

Results: All participants completed this study without any significant adverse effects. FOG-Q and turn steps revealed significant improvements over time in the rTMS compared with the sham stimulation (χ 2=6.067, p=0.048 and χ 2=9.083, p=0.011). In addition, the TUG task and UPDRS-III showed significant improvements over time in the rTMS compared with the sham stimulation (χ 2=7.200, p=0.02 and χ 2=7.000, p=0.030).

Conclusion: Cumulative HF-rTMS over the M1-LL might be effective for improving freezing of gait in patients with atypical Parkinsonism. Further investigation with a large number of participants is needed to clarify the effects of HFrTMS on freezing of gait in atypical Parkinsonism.

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Keywords: ATYPICAL PARKINSONISM; BRAIN STIMULATION; FREEZING OF GAIT; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; VASCULAR PARKINSONISM

Document Type: Short Communication

Publication date: October 1, 2016

More about this publication?
  • Journal of Rehabilitation Medicine is the international peer-reviewed journal published in English, with at least 10 issues published per year.

    Original articles, reviews, case reports, short communications, special reports and letters to the editor are published, as also are editorials and book reviews. The journal strives to provide its readers with a variety of topics including: functional assessment and intervention studies, clinical studies in various patient groups, methodology in physical and rehabilitation medicine, epidemiological studies on disabling conditions and reports on vocational and sociomedical aspects of rehabilitation.

    The journal is read by a wide group of healthcare professionals including specialists in rehabilitation medicine, neurology, clinical neurophysiology, general medicine, psychologists, physiotherapists, occupational therapists and social workers.

    Contributions from all parts of the world and from different professions in rehabilitation are welcome.

    ISI Impact Factor 2009: 1.882.

    Owned by Foundation of Rehabilitation Information.

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