The Directed ortho Metallation–Cross-Coupling Fusion: Development and Application in Synthesis
This review constitutes a detailed but non-exhaustive examination of the directed ortho metallation (DoM)–cross-coupling fusion in its many flavours. Special attention is paid to the application of the concept of the linked reactions and the synthetic utility that it endows, particularly
in the case of one-pot reactions that can greatly increase the ease and efficiency of the process. Personal experience of particular issues that can arise from these reactions and examples of their solutions are given, as well as illustrations of the rapid access to complex molecules that
the technique encourages.
Document Type: Research Article
Publication date: 01 October 2013
Johnson Matthey's journal of research on the platinum group metals and developments in their application in industry from 1957-2014. It has now been renamed the Johnson Matthey Technology Review
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