Skip to main content
padlock icon - secure page this page is secure

Open Access Production of No-Carrier-Added 105Rh from Neutron Irradiated Ruthenium Target

Download Article:
(HTML 45.4 kb)
(PDF 462.2 kb)
Nuclear medicine radiotherapy involves the administration of a radiolabelled drug whose purpose is tissue damage and/or destruction at the point of localisation. Radionuclides useful for this application are those which emit particles (that is alpha, beta or Auger electrons) because they deposit their decay energy over a relatively short range (for example, at the tumour site). Rhodium-105 is a radionuclide with desirable nuclear properties for therapeutic applications (its half-life is 35.4 hours, the maximum α- energy is 0.56 MeV and it produces a 319 keV γ-ray suitable for imaging). However, this radionuclide is not readily available to most of the interested investigators due to the difficulty in production scale-up. The work reported here was designed to develop a viable method to produce and purify multi-millicurie quantities of 105Rh for radiotherapy research. Rhodium-105 was produced at the University of Missouri Research Reactor by the nuclear reaction, 104Ru (n, γ) → 105Ru (β- decay) → 105Rh and a new procedure was developed to chemically separate the no-carrier-added 105Rh from the neutron irradiated ruthenium target. Rhodium-105 production yields, for 10 runs, averaged about 5 mCi per milligram of ruthenium from a 72-hour irradiation at a thermal neutron flux of 8 × 1013 neutrons cm-2 s-1. Rhodium-105 was successfully isolated from the ruthenium radionuclides and the non-radioactive ruthenium. This new separation technique was fast (a total time of 3 hours) and highly efficient for removing the ruthenium. The decontamination factor of ruthenium averaged 16,600, indicating that only 0.006 per cent of the ruthenium remained after separation.

19 References.

No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Publication date: April 1, 2000

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more