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Study of dual responsive poly[(maleilated dextran)‐graft‐(N‐isopropylacrylamide)] hydrogel nanoparticles: preparation, characterization and biological evaluation

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BACKGROUND: Much interest has recently been shown in fundamental studies and technological developments of polymeric nanoparticles. Novel dual temperature‐ and pH‐sensitive stabilized nanoparticles composed of maleilated dextran (Dex‐MA) and N‐isopropylacrylamide (NIPAAm) were prepared and investigated to be used for the controlled release of 10‐hydroxycamptothecin.

RESULTS: The resultant nanoparticles showed spherical geometry, with diameters ranging from 60 to 300 nm, the variation achieved by adjusting the composition ratio or the amounts of surfactant. The size of the nanoparticles increased and the zeta potential reversed with an increase of pH. Also, the lower critical solution temperature (LCST) decreased at pH = 3.0, but increased at pH = 6.0, which suggests that the LCST is dependent on pH. Drug release results obtained showed encapsulation and loading efficiencies were 62.9% and 0.82%, respectively. Cytotoxicity assay of this copolymer indicated no significant toxicity.

CONCLUSION: Novel dual temperature‐ and pH‐sensitive Dex‐MA‐graft‐PNIPAAm nanoparticles may provide some advantages for anti‐cancer drug delivery due to a tunable LCST from 35 to 45 °C and controllable dimensions. These nanoscale materials could be excellent candidates for biotechnology and biomedical applications. Copyright © 2009 Society of Chemical Industry
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Keywords: NIPAAm; hydrogel nanoparticles; maleilated dextran; temperature and pH sensitivity

Document Type: Research Article

Publication date: September 1, 2009

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