Skip to main content
padlock icon - secure page this page is secure

Growth factors in the treatment of diabetic foot ulcers

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.


Chronic foot ulceration is a major source of morbidity in diabetic patients. Despite traditional comprehensive wound management, including vascular reconstruction, there remains a cohort of patients with non-responding wounds, often resulting in amputation. These wounds may benefit from molecular manipulation of growth factors to enhance the microcirculation.


A review of the current literature was performed using Pubmed, with secondary references obtained from key articles.

Results and conclusion:

There has been a generally disappointing clinical outcome from growth factor trials, although topical platelet-derived growth factor has shown significant benefit and should be considered in non-healing, well perfused ulcers after failure of conventional wound care. The modulatory role of the extracellular matrix in the cellular response to growth factors and data from regenerative-type fetal wound healing are further areas of interest. The chemical induction of microvessel formation may become a future therapeutic option. Copyright © 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons Ltd
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Review Article

Affiliations: 1: Unit of Cell and Molecular Biology, The Dental School, University of Dundee, Dundee, UK 2: Department of Vascular Surgery, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK 3: Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

Publication date: February 1, 2003

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more