Skip to main content
padlock icon - secure page this page is secure

Bone assessment in patients with ileal pouch-anal anastomosis for inflammatory bowel disease

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Background Patients with ulcerative colitis are at risk of low bone mineral density (BMD). Proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis diminishes the risk of bone disease. The aims of this study were to assess the mechanism of low BMD and to measure bone density changes after IPAA.

Methods Twenty patients with IPAA for ulcerative colitis, of mean(s.d.) age 38(9) (range 21-58) years, had measurements of lumbar spine and femoral neck BMD by dual energy X-ray absorptiometry, a mean(s.d.) 28(23) (range 3-84) months after proctocolectomy. Serum levels of calcium, phosphate, parathyroid hormone, osteocalcin and 25-hydroxy vitamin D were determined. Fifteen patients were followed for 28(12) (range 8-50) months.

Results At baseline, six patients had spine BMD more than two standard deviations below the normal value, and three had vertebral crush fractures. Mean vitamin D values were normal and no patient had osteomalacia. BMD increased with time elapsed since IPAA (spine: r=0·71, P=0·005). During follow-up, mean(s.d.) changes in bone density were +2·3(3·8) and +2·1(5·6) per cent per year at the spine and femoral neck respectively.

Conclusion These results suggest that in patients with IPAA for ulcerative colitis, low BMD is not associated with vitamin D malabsorption and may be reversible after surgery.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Service d'Hepato-Gastroenterologie 2: Clinique de Rhumatologie, Hopital Cochin 3: Laboratoire de Biochimie, Faculte de MedecinePitie-Salpetriere 4: Service de Chirurgie Digestive, Hopital Lariboisiere, Paris, France

Publication date: November 1, 1997

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more