Skip to main content
padlock icon - secure page this page is secure

Preventing postoperative recurrence of Crohn's disease

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Background and methods Risk factors for recurrence of Crohn's disease and the evidence for progress in reducing recurrence following resection were reviewed. A Medline based literature review was carried out.

Results and conclusion Only smoking has been confirmed as a significant adverse risk factor for recurrence. Evidence for differing recurrence rates in fibrostenosing disease and perforating disease is inconclusive, but such a classification along with the endoscopic findings of recurrence may have a place in the analysis of therapeutic trials. Minimal resectional surgery with clearing of only macroscopic disease seems to be justified, with no clear benefits from different anastomotic techniques. Recent trials offer encouraging evidence of the usefulness of 5-aminosalicylic acid, particularly higher-dose regimens started early after resection, although the long-term benefits are uncertain. The oral steroid, budesonide, offers a potent treatment with minimal side-effects, but evidence of its prevention of recurrence is presently weak.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Miscellaneous

Affiliations: 1: Departments of Surgery 2: Gastroenterology, John Radcliffe Hospital, Oxford OX3 9DU, UK

Publication date: November 1, 1997

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more