Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer
Methods This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years. Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database. For the past 4 years each case has been re-evaluated where possible.
Results Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies. Only three cases (0·3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis. A total of 16 patients (1·4 per cent) fulfilled looser criteria for HNPCC.
Conclusion This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.
Document Type: Research Article
Affiliations: 1: Department of Medical Genetics, St Mary's Hospital 2: Department of Clinical Studies, Trafford General Hospital 3: Centre for Cancer Epidemiology, Christie Hospital, Manchester, UK
Publication date: September 1, 1997