Electrically stimulated smooth muscle neosphincter
Methods Electrical stimulation of the rabbit colon was performed via intramural wire electrodes using a constant voltage DC stimulator. Contractile activity was recorded by serosal strain gauges and an intraluminal pressure probe.
Results Basal colonic pressure was 4-13 (median 11) cmH2O. Peak pressures generated by stimulated contractions (10 V, 1 ms, 10 Hz) ranged from 14 to 37 (median 26, n=36) cmH2O and were significantly higher than those with spontaneous contractions (P=0·005). During continuous stimulation contractions lasted for 45-96 (median 74) s. Intermittent stimulation using trains of electrical pulses of 1-2-min duration at 1-2-min intervals produced repeated contractions. Alternative contractions were produced when intermittent electrical stimulation was performed at two sites alternately with two pairs of electrodes more than 2·5 cm apart, producing a sustained high-pressure zone.
Conclusion An electrically stimulated smooth muscle neosphincter is feasible. It has potential applications in the management of faecal incontinence.
Document Type: Research Article
Affiliations: 1: Academic Department of Surgery and * 2: Gastrointestinal Science Research Unit, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
Publication date: September 1, 1997