Presence of granulomas is associated with recurrence after surgery for Crohn's disease: experience of a surgical unit
Methods Separate survival curves were estimated for each variable. A multivariate analysis was then carried out in which several selected explanatory variables were included simultaneously in a proportional hazards regression model.
Results Operation for recurrent disease was necessary in 36 patients. Univariate analysis revealed a highly significant relationship between the presence of granulomas and subsequent recurrence (P=0·003). There was a trend towards increased recurrence in patients with ileocolonic disease and segmental colectomy (P=0·11 and P=0·1 respectively). Age, sex, length of history, indication for operation and affected lines of transection were not associated with recurrence. After multivariate analysis, the association of granulomas with recurrence remained significant (P=0·03). This association persisted when death was regarded as a treatment failure (P=0·02).
Conclusion The presence of granulomas in patients with Crohn's disease is significantly associated with recurrence.
Document Type: Research Article
Affiliations: 1: Departments of Surgery and 2: Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia 3: Histopathology, The Royal Newcastle Hospital and
Publication date: January 1, 1997