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A brief review on toxicity of silver nanoparticles

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Nanotechnology has been expanding rapidly in recent years.In this context,the number of commercial products comprising nanomaterials is increasing.Among the commercially available nano-sized materials,silver nanoparticles are by far the most frequently used nanocompounds owing to its special antimicrobial activity.However, there is an increasing concern related to the biological safety of the use of silver nanoparticles on a large scale.In this review,we present the new discoveries in the toxicity of silver nanoparticles from the viewpoint of in vitro cytotoxicity to mammalian,in vivo toxicity to mammalian animals,toxicity to non-mammalian animals,as well as genotoxicity and carcinogenicity.The possible mechanisms of silver nanoparticle-induced toxicity are also discussed.

PLEASE NOTE: The full text of this publication is in Chinese.

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Keywords: biological safety; carcinogenicity; genotoxicity; in vitro cytotoxicity; in vivo toxicity; silver nanoparticles

Document Type: Research Article

Affiliations: 1: National Beijing Center for Drug Safety Evaluation and Research Beijing Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing 100850 China 2: Institute for Medical Device Control National Institutes for Food and Drug Control Beijing 100050 China

Publication date: January 1, 2013

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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