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HPLC determination of jolkinolide A and jolkinolide B inChinese herb medicine“Lang-du”

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To establish a method for the determination of two diterpenoide lactonesjolkinolide A and jolkinolide B in Chinese herbal medicine “Lang-du” by HPLC.Methods:C18column(4.6 mm ×250 mm5 μm)was used with acetonitrile-water(75:25)as the mobile phase.The flow rate was 1.0 mL·min-1and the detection wavelength was 250 nm.Results:By using the established HPLC methodnine samples of “Lang-du” were analyzed to determine the contents of jolkinolide A and B.It was showed that the contents of jolkinolide A and B ranged from 0.007% to 0.043% and 0.012% to 0.204%respectively.Among the samplesthe two diterpenoids were found in most of the samples of Euphorbia fischeriana and E.ebracteolatabut Stellera chamaejasme and Alocasia macrorrhiza contained neither jolkinolide A nor jolkinolide B.Conclusion:A simpleeffective and feasible HPLC method with good accuracyprecision and reproducibility to determine the contents of two diterpenoids in“Lang-du” was established which could be applied for the quality control of this herb.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: E.ebracteolata; Euphorbia fischeriana; HPLC; determination; jolkinolide A; jolkinolide B

Document Type: Research Article

Publication date: September 1, 2006

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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