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Home / Public Health Action, Volume 13, Number 3

Open Access Shorter TB treatment regimens should be safer as well

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Authors: Rucsineanu, O. 1 ; Agbassi, P. 2 ; Herrera, R. 2 ; Low, M. 3 ; McKenna, L. 4 ; Stillo, J. 5 ; Winarni, P. 2 ; Acharya, A. 6 ; Sari, A. H. 2 ; 

Source: Public Health Action, Volume 13, Number 3, 21 September 2023, pp. 104-106(3)

Publisher: International Union Against Tuberculosis and Lung Disease

DOI: https://doi.org/10.5588/pha.23.0026

This article is Open Access under the terms of the Creative Commons CC BY licence.

Most ongoing and planned TB therapeutic trials are focused on shortening the duration of treatment while giving less consideration to other aspects of TB care that are important to people with TB. Here we argue that other variables besides duration of TB treatment should also be considered when developing new TB treatment regimens, including drug toxicity, time spent in monitoring and overall quality of life while on therapy. We examine the specific use of linezolid in treatment-shortening trials for drug-susceptible TB and propose additional endpoints that should be prioritised in TB treatment studies.

Keywords: person-centred; safer; shorter; toxicity

Document Type: Research Article

Affiliations: 1: Moldova National Association of Tuberculosis Patients “SMIT” (Society of Moldova against Tuberculosis), Balti, Moldova, Global TB Community Advisory Board, New York, NY, USA 2: Global TB Community Advisory Board, New York, NY, USA 3: Department of Computer Science, University of Cape Town, Cape Town, South Africa 4: Global TB Community Advisory Board, New York, NY, USA, Treatment Action Group, New York, NY, USA 5: Global TB Community Advisory Board, New York, NY, USA, Department of Anthropology, Wayne State University, Detroit, MI, USA 6: Independent Consultant, Mumbai, India

Publication date: September 21, 2023

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  • Public Health Action (PHA), The Union's quarterly Open Access journal, welcomes the submission of articles on operational research. It publishes high-quality scientific research on health services, providing new knowledge on how to improve access, equity, quality and efficiency of health systems and services.

    The Editors will consider any manuscript reporting original research on quality improvements, cost-benefit analysis, legislation, training and capacity building, with a focus on all relevant areas of public health (e.g. infection control, nutrition, TB, HIV, vaccines, smoking, COVID-19, microbial resistance, outbreaks etc).

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