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Home / Public Health Action, Volume 11, Number 2

Open Access Laboratory comparison of stool processing methods for Xpert® Ultra

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TB disease diagnosis in children is difficult due to non-specific symptoms, paucibacillary disease and the need for invasive procedures to obtain diagnostic specimens. In many settings, these specimens are simply not collected and therefore stool, easily obtained, has emerged as a promising specimen for the diagnosis of child TB. In this study, stool from a healthy adult was spiked with known concentrations of bacille Calmette-Guérin vaccine and tested using the Xpert® Ultra assay to determine the relative detection and error rate associated with four different published stool processing methods.

Keywords: child; diagnosis; tuberculosis

Document Type: Research Article

Affiliations: 1: United States Peace Corps, Mbabane, Eswatini, Baylor College of Medicine Children’s Foundation-Eswatini, Mbabane, Eswatini 2: Baylor College of Medicine Children’s Foundation-Eswatini, Mbabane, Eswatini 3: Eswatini National Health Services Laboratory, Mbabane, Eswatini 4: Eswatini National Tuberculosis Control Program, Manzini, Eswatini 5: Baylor College of Medicine, Houston, TX, USA 6: Department of Population Health Sciences, Geisinger, Danville, VA, USA 7: Baylor College of Medicine Children’s Foundation-Eswatini, Mbabane, Eswatini, Baylor College of Medicine, Houston, TX, USA

Publication date: June 21, 2021

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  • Public Health Action (PHA), The Union's quarterly Open Access journal, welcomes the submission of articles on operational research. It publishes high-quality scientific research on health services, providing new knowledge on how to improve access, equity, quality and efficiency of health systems and services.

    The Editors will consider any manuscript reporting original research on quality improvements, cost-benefit analysis, legislation, training and capacity building, with a focus on all relevant areas of public health (e.g. infection control, nutrition, TB, HIV, vaccines, smoking, COVID-19, microbial resistance, outbreaks etc).

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