@article {Walker:2019:2220-8372:42,
title = "Depression and anxiety in patients with multidrug-resistant tuberculosis in Nepal: an observational study",
journal = "Public Health Action",
parent_itemid = "infobike://iuatld/pha",
publishercode ="iuatld",
year = "2019",
volume = "9",
number = "1",
publication date ="2019-03-21T00:00:00",
pages = "42-48",
itemtype = "ARTICLE",
issn = "2220-8372",
eissn = "2220-8372",
url = "https://www.ingentaconnect.com/content/iuatld/pha/2019/00000009/00000001/art00008",
doi = "doi:10.5588/pha.18.0047",
keyword = "epidemiology, common mental disorders, drug resistance, comorbidity, infectious disease",
author = "Walker, I. F. and Kanal, S. and Baral, S. C. and Farragher, T. M. and Joshi, D. and Elsey, H. and Newell, J. N.",
abstract = "
Setting: Multidrug-resistant tuberculosis (MDR-TB) patients in the national TB treatment programme of Nepal.
Objective: To estimate the prevalence of depression and anxiety in people receiving treatment for MDR-TB, identify potential risk factors for depression and
anxiety and determine temporal changes in their severity during treatment.
Design: An observational study using a screening tool, the Hopkins Symptom Checklist (HSCL-25) for depression and anxiety, administered monthly to a group of 135 patients in Nepal. Logistic and multilevel
linear regression models were used to identify any patient characteristics associated with depression and anxiety.
Results: Most of the 135 patients were male (76%) and living with their families (68%). The period prevalences of depression and anxiety were respectively 22.2% and
15.6%. Patients reporting physical side effects of MDR-TB treatment had a higher depression score on HSCL by 2.63 points (95%CI 0.774.48) and a 1.59 point higher anxiety score (95%CI 0.452.73) than those who did not report any side effects. Being single was associated with having
anxiety (aOR 0.2, 95%CI 0.031.0).
Conclusion: Given the high rates of depression observed among MDR-TB patients, national TB treatment programmes should ensure their patients are routinely screened for depression and anxiety, and effective treatment offered.",
}