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Open Access Risk factors for unfavourable treatment outcome among new smear-positive pulmonary tuberculosis cases in China

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Setting: Three projects of the Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB.

Objectives: To assess unfavourable treatment outcomes (UTOs), including failure, died, loss to follow-up (LTFU), transferred out and unknown outcome, and to identify risk factors associated with UTOs.

Design: This was a cross-sectional study using routine programme data.

Results: Of 30 277 new smear-positive tuberculosis (TB) patients, 4261 (14.1%) had UTOs: 2048 (6.8%) LTFU, 1418 (4.7%) transferred out, 390 (1.3%) died, 340 (1.1%) failed and 65 (0.2%) had an unknown outcome. Risk factors for LTFU (including LTFU, transfer out and unknown outcome) were residing in Anhui, age > 55 years, service delay > 10 days, patient delay < 30 days, directly observed treatment (DOT) provided by a family member or others and unknown DOT provider. The outcome of ‘died’ was associated with residing in Shaanxi, age > 55 years, male sex, patient delay > 30 days and unknown DOT provider. ‘Failed’ was associated with having unlimited access to health services, patient delay of >30 days and unknown DOT provider.

Conclusion: This study highlights the predominance of lost patients among UTOs. Patients with family members or other non-medical DOT providers or unknown DOT providers had a high risk of a UTO. There is an urgent need to address these service-related factors.
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Keywords: China; risk factor; tuberculosis; unfavourable outcome

Document Type: Research Article

Affiliations: 1: International Union Against Tuberculosis and Lung Disease (The Union), Beijing, China, The Union, Paris, France 2: The Union, Paris, France 3: Beijing Chest Hospital, Capital Medical University, Beijing, China, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China

Publication date: December 21, 2017

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  • Public Health Action (PHA), The Union's quarterly Open Access journal, welcomes the submission of articles on operational research. It publishes high-quality scientific research on health services, providing new knowledge on how to improve access, equity, quality and efficiency of health systems and services.

    The Editors will consider any manuscript reporting original research on quality improvements, cost-benefit analysis, legislation, training and capacity building, with a focus on all relevant areas of public health (e.g. infection control, nutrition, TB, HIV, vaccines, smoking, COVID-19, microbial resistance, outbreaks etc).

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