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Open Access Symptom reporting among prevalent tuberculosis cases who smoke, are HIV-positive or have hyperglycaemia

Data from a tuberculosis (TB) prevalence survey conducted in 24 communities in Zambia and the Western Cape, South Africa, January–December 2010, were analysed to determine the influence of smoking, hyperglycae-mia and human immunodeficiency virus (HIV) infection on TB symptom reporting in culture-confirmed TB cases. Of 123 790 adults eligible for enrolment, 90 601 (73%) consented and 64 463 had evaluable sputum samples. ORs and 95%CIs were calculated using a robust standard errors logistic regression model adjusting for clustering at community level. HIV-positive TB cases were more likely to report cough, weight loss, night sweats and chest pain than non-HIV-positive TB cases. TB cases who smoked or had hyperglycaemia did not report symptoms differently from cases without these comorbidities.

Keywords: case finding; comorbidities; screening

Document Type: Research Article

Affiliations: 1: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa 2: South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, Cape Town, South Africa 3: London School of Hygiene & Tropical Medicine, London, UK 4: ZAMBART Project, University of Zambia Ridgeway Campus, Lusaka, Zambia

Publication date: December 21, 2014

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