Stool testing for pulmonary TB diagnosis in adults
METHODS: Embase and PubMed were searched to identify studies with data on stool testing among patients with clinically presumed or microbiologically verified PTB.
RESULTS: Thirteen relevant studies were included. A pooled sensitivity of one or more of the three TB identifying methods was 79.1% (95% CI 61.5–92.5). The sensitivity of stool microscopy, PCR and culture was respectively 41.1% (95%CI 24.9–58.2), 89.7% (95% CI 81.4–95.9) and 38.0% (95% CI 26.2–50.6). The heterogeneity of the studies included was high.
CONCLUSION: Our review findings indicate that the analysis of stool specimens as part of PTB diagnostics is useful. PCR methods were particularly helpful in detecting a substantial proportion of patients with PTB.
Keywords: Mycobacterium tuberculosis; PCR; diagnostic methods; faeces; sensitivity
Document Type: Research Article
Affiliations: 1: Department of Infectious Diseases, Aarhus University Hospital, Aarhus University, Aarhus, Denmark 2: Department of Infectious Diseases, Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Department of Public Health, Center for Global Health (GloHAU), Aarhus University, Aarhus, Denmark
Publication date: June 1, 2022
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