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Clinical effects of TB sequelae in patients with COPD

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BACKGROUND: TB is a risk factor for chronic obstructive pulmonary disease (COPD) development and causes the global burden of COPD to increase. The impact of TB sequelae on COPD has been ignored for years.

OBJECTIVE: To determine the prevalence of TB sequelae in patients with COPD and investigate the effect of TB sequelae on COPD clinic burden.

METHODS: A total of 172 patients who attended the chest diseases outpatient clinic were included in the study. Detailed anamneses of their TB were taken, and pulmonary function tests were performed. The COPD Assessment Test (CAT) questionnaire was administered to determine the health status, and the modified Medical Research Council (mMRC) scale was used to assess the severity of dyspnoea. Thorax computed tomography images were reviewed. The patients were divided into two groups based on the presence of TB sequelae. All data from the two groups were compared.

RESULTS: Of 172 patients with COPD, 66 (38%) had TB sequelae; 28 (46%) patients with TB sequelae had no history of TB. Two patients with TB history had no TB sequelae. The group with TB sequelae had lower body mass index (P < 0.001), more emergency admissions (P = 0.018), and higher CAT and mMRC scores (P = 0.002 and P = 0.004, respectively). In the group with TB sequelae, bronchiectasis was more common (P = 0.001).

CONCLUSION: In patients with COPD, TB sequelae are very common and increase the COPD clinic burden. The presence of TB sequelae causes an increase in the use of healthcare services by patients with COPD and, therefore, an increase in the burden of COPD. Prevention, early diagnosis and timely treatment of TB are therefore very important.

Keywords: COPD; bronchiectasis; dyspnoea; health status; tuberculosis

Document Type: Research Article

Affiliations: 1: Department of Chest Diseases, Dr Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey 2: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkey 3: Department of Radiology, Medical Park Hospital, Izmir Economy University, Izmir, Turkey

Publication date: April 1, 2022

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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