Impact of lung function on treatment outcome in patients with TB
METHODS: A retrospective cohort study on data from all consecutive patients with culture-confirmed PTB and available spirometry test results admitted during the year 2016 to the Regional anti-TB dispensary no.1 in Kharkiv, Ukraine.
RESULTS: A total of 278 patients with PTB were included into the study. The rate of negative treatment outcome (failure or death) was higher in patients with restrictive and mixed lung dysfunction than in those with normal spirometry results (25.6% vs. 6.8%, P = 0.0007; 37.5% vs. 6.8%, P = 0.003, respectively). In a logistic regression model, restrictive lung disease and mixed-type lung disease were associated with negative treatment outcome (OR 4.19, 95% CI 1.60–13.28, P = 0.007 and OR 5.46, 95% CI 1.28–24.44, P = 0.02, respectively).
CONCLUSIONS: Lung function at the time of diagnosis has an important impact on treatment outcomes in patients with PTB; the more severe the restriction in lung function the higher the likelihood of a negative treatment outcome.
Keywords: FEV1; FVC; obstruction; restriction; spirometry; tuberculosis
Document Type: Research Article
Affiliations: 1: Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany, German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Germany 2: Kharkiv National Medical University, Kharkiv, Ukraine 3: Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany, German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Germany 4: Kharkiv National Medical University, Kharkiv, Ukraine, VN Karazin Kharkiv National University, Kharkiv, Ukraine 5: Regional Anti-TB Dispensary 1, Kharkiv, Ukraine 6: Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany, German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Germany, Respiratory Medicine/International Health, University of Lübeck, Lübeck, Germany, Department of Medicine, Umeå University, Umeå, Sweden
Publication date: April 1, 2021
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