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Free Content Tuberculosis trends in a hot-spot region in Paris, France

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SETTING: Tuberculosis (TB) incidence is declining overall in France, but not in Paris where some areas remain relative hot spots for TB.

OBJECTIVES: To obtain a better knowledge of local TB epidemiology in order to facilitate control measures.

DESIGN: Analysis of demographic data of TB patients diagnosed at the Bichat-Claude Bernard Hospital from 2007 to 2016, with spoligotyping of Mycobacterium tuberculosis complex isolates.

RESULTS: During the study period, 1096 TB patients were analysed. The incidence of TB diagnosis was stable, averaging 115 patients per year, predominantly males (71%), foreign-born (81%), with pulmonary TB (77%) and negative HIV serology (88%). The mean age of foreign-born TB patients decreased over the study period, most significantly in recent arrivals in France, whose average age decreased by two years (P = 0.001). The time period between arrival in France and being diagnosed with active TB decreased annually significantly by 0.75 years (P = 0.02). The proportion of L4.6.2/Cameroon and L2/Beijing sub-lineages increased annually by 0.7% (P < 0.05). Multi-drug resistant strains, representing 4% of all strains, increased annually by 0.75% (P = 0.03)

CONCLUSION: The number of TB patients remained high in northern Paris and the surrounding suburbs, suggesting the need for increased control measures.
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Keywords: France; Mycobacterium tuberculosis; epidemiology; spoligotyping

Document Type: Research Article

Affiliations: 1: Mycobacterial Genetics Unit, Institut Pasteur, Paris, Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China 2: Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal 3: Mycobacterial Genetics Unit, Institut Pasteur, Paris, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China 4: Statistic Study Group, Ecole Polytechnique, Palaiseau 5: Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, IAME, UMR 1137, Institut national de la santé et de la recherche médicale, Université Paris Diderot, Sorbonne Paris Cité F-75018, Paris 6: Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, Laboratoire de Bactériologie, Centre Hospitalo-Universitaire, Nice 7: Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, IAME, UMR 1137, Institut national de la santé et de la recherche médicale, Université Paris Diderot, Sorbonne Paris Cité F-75018, Paris 8: Mycobacterial Genetics Unit, Institut Pasteur, Paris 9: Institute for Integrative Biology of the Cell (I2BC), CEA, Centre national de la Recherche scientifique, Université Paris Sud, Université Paris Saclay, Gif-sur-Yvette, France 10: Mycobacterial Genetics Unit, Institut Pasteur, Paris, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela

Publication date: April 1, 2020

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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