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Free Content Risk factors for unfavourable treatment outcomes among rifampicin-resistant tuberculosis patients in Tajikistan

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SETTING: Tajikistan is among the 30 countries with the highest multidrug-resistant tuberculosis (MDR-TB) burden.

OBJECTIVE: To investigate the risk factors for unfavourable treatment outcomes among rifampicin-resistant (RR)/MDR-TB patients.

DESIGN: Retrospective medical chart review of RR/MDR-TB patients enrolled for treatment in 2012–2013.

RESULTS: Of 601 RR/MDR-TB patients, 58 (9.7%) had pre-extensively drug-resistant TB (pre-XDR-TB; i.e., MDR-TB with additional resistance to a fluoroquinolone or second-line injectable agent) and 45 (8%) had XDR-TB (MDR-TB with additional resistance to both). Treatment failure and death were reported in respectively 40 (7%) and 89 (15%) cases; 60 (10%) patients were lost to follow-up (LTFU). In multivariable analysis, treatment failure was associated with pre-XDR-TB (adjusted odds ratio [aOR] 3.67, 95%CI 1.47–9.18) or XDR-TB (aOR 8.61, 95%CI 3.48–21.34). Death was associated with age >45 years vs. <25 years (aOR 3.47, 95%CI 1.68–7.19) and no record of any adverse event during treatment (aOR 2.55, 95%CI 1.48–4.39). Changing place of residence during treatment was an independent predictor of LTFU (aOR 4.61, 95%CI 2.41–8.8).

CONCLUSIONS: Our findings highlight the need for 1) the use of regimens with new anti-tuberculosis drugs; 2) good handover of TB patients and 3) effective tracing mechanisms if patients change a place of residence to prevent LTFU.
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Keywords: adverse event; loss to follow-up; retrospective cohort study; second-line anti-tuberculosis drug; treatment failure

Document Type: Research Article

Affiliations: 1: KNCV Tuberculosis Foundation, Country Office, Dushanbe 2: USAID TB Control Project, Dushanbe 3: National Centre of Population Protection from Tuberculosis, Dushanbe, Tajikistan 4: Technical Division, Team Evidence, KNCV Tuberculosis Foundation, The Hague, The Netherlands 5: Technical Division, Team Evidence, KNCV Tuberculosis Foundation, The Hague, The Netherlands, Department of Public Health, Epidemiology, and Biostatistics, David Tvildiani Medical University, Tbilisi, Georgia

Publication date: March 1, 2019

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

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