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Free Content Latent tuberculous infection among foreign-born individuals applying to shelters in the metropolitan area of Milan

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SETTING: Screening for latent tuberculous infection (LTBI) of groups at high risk of active tuberculosis (TB) is a key component of the End TB Strategy.

OBJECTIVE: To conduct a retrospective descriptive analysis of LTBI rates among foreign-born individuals applying to shelters in the metropolitan area of Milan, Italy.

DESIGN: All foreign-born individuals registering for accommodation centres in the city of Milan from November 2009 to April 2017 were screened for active TB and LTBI. Individuals aged <36 years with a tuberculin skin test (TST) induration of >10 mm were offered confirmatory testing with QuantiFERON®-TB Gold In-Tube (QFT-GIT).

RESULTS: Of the 2666 TST-positive migrants aged <36 years who underwent LTBI confirmation testing, 1322 (49.6%) tested negative, 1339 (50.2%) were positive and five (0.2%) had indeterminate results. In the multivariate analysis, TB incidence in the country of origin and age were significantly associated with QFT-GIT positivity. Although estimated TB incidence in Eritrea, Morocco and Romania was 100/100 000 person-years (py), the probability of being QFT-GIT-positive in individuals from these countries were not statistically significantly different from individuals from countries with TB incidence > 250/100 000 person-years.

CONCLUSION: Our data showed a high proportion of LTBI among individuals coming from intermediate TB burden countries.
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Keywords: LTBI; migrant; screening

Document Type: Research Article

Affiliations: 1: Emerging Bacterial Pathogens Unit, Division of Immunology and Infectious Diseases, Istituto di ricovero e cura a carattere scientifico San Raffaele, Milan 2: Regional TB Reference Centre and Laboratory, Villa Marelli Institute, Niguarda Ca' Granda Hospital, Milan 3: University Centre of Statistics for Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy 4: Section of Respiratory Disease, Department of Internal Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden 5: Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Perugia 6: Institute of Respiratory Medicine, University of Milan, San Paolo Hospital, Milan, Italy

Publication date: October 1, 2018

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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