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Hyperbaric oxygen therapy increases the risk of tuberculosis disease
OBJECTIVE: To evaluate the effect of HBOT on TB reactivation.
DESIGN: Our study sample was from the National Health Insurance Research Database containing one million beneficiaries. We identified a group of patients who underwent HBOT, and matched this group with individuals without HBOT. We compared the incidence of activation of TB between these two groups.
RESULTS: A total of 2258 patients were identified, with each group comprising 1129 patients. One year after exposure to hyperbaric oxygen, the number of cases of active TB was significantly higher in the HBOT group than in the non-HBOT group (11 cases vs. 1 case, P = 0.006). Multiple regression analysis showed that HBOT was the only statistically significant contributor to TB activation.
CONCLUSION: HBOT is likely to trigger the reactivation of TB. High-risk patients should undergo the tuberculin skin test or interferon-gamma release assays before HBOT to identify patients with LTBI.
Keywords: HBO; LTBI; hyperbaric oxygen; latent tuberculous infection; tuberculosis
Document Type: Research Article
Affiliations: 1: Division of Plastic and Reconstructive Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City 2: Division of Plastic and Reconstructive Surgery, National Taiwan University Hospital Yulin Branch, Yulin 3: Division of Infectious Disease, Kaohsiung Veterans General Hospital, Kaohsiung 4: Critical Care Center and Cardiovascular Medical Center, Kaohsiung Veterans General Hospital, Kaohsiung 5: Division of Plastic and Reconstructive Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Institute of Emergency & Critical Care Medicine, National Yang-Ming University, Taipei City, Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan
Publication date: 01 June 2018
The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.
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