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Free Content Prevalence of latent tuberculous infection among adults in the general population of Ca Mau, Viet Nam

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SETTING: The study was conducted in a randomly selected sample of persons aged 15 years living in Ca Mau Province, southern Viet Nam.

OBJECTIVE: To estimate the prevalence of latent tuberculous infection (LTBI) in the general adult population of this province of Viet Nam. The secondary objective was to examine age and sex differences in prevalence.

DESIGN: A cross-sectional survey was conducted in a cluster-random sample of the population. Clusters were subcommunes. The presence of LTBI was assessed using the QuantiFERON®-TB Gold In-Tube test system.

RESULTS: QuantiFERON tests were performed among 1319 persons aged 15 years (77.7% of those selected). The overall prevalence of positive tests was 36.8% (95%CI 33.4–40.3). The prevalence of a positive test was lower in females than in males (31.0% vs. 44.7%, OR 0.57, 95%CI 0.45–0.72, P < 0.0001). The prevalence of positive tests increased with increasing age quintile (P < 0.0001).

CONCLUSION: More than one third of the general adult population in a province in southern Viet Nam have evidence of LTBI. Although LTBI prevalence is higher in males, the sex difference is not as great as that for TB notification rates.
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Keywords: IGRA; LTBI; QuantiFERON®; epidemiology; interferon-gamma release assay

Document Type: Research Article

Affiliations: 1: Woolcock Institute of Medical Research, Hanoi, Viet Nam, South Western Sydney Clinical School, University of New South Wales, Sydney, University of Sydney, Sydney, New South Wales, Australia 2: National Lung Hospital, Hanoi, National TB Control Programme, Hanoi, Viet Nam 3: Woolcock Institute of Medical Research, Hanoi, Viet Nam, University of Sydney, Sydney, New South Wales, Australia 4: National Lung Hospital, Hanoi, National TB Control Programme, Hanoi, Viet Nam, Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France 5: National TB Control Programme, Hanoi, Viet Nam, Centre for Social Disease Control, Ca Mau, Viet Nam 6: Woolcock Institute of Medical Research, Hanoi, Viet Nam 7: Woolcock Institute of Medical Research, Hanoi, Viet Nam, South Western Sydney Clinical School, University of New South Wales, Sydney

Publication date: 01 March 2018

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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