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Free Content Tuberculosis in recipients of solid-organ transplants during 1995–2015 in Cali, Colombia

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SETTING: Tuberculosis (TB) in solid-organ transplants (SOTs) is an important opportunistic infection associated with mortality and graft loss. SOT recipients carry a higher risk of contracting active TB than the general population. Clinical and radiographic presentations are non-specific, and sputum smear and culture have low yields. TB patients with SOTs require standard anti-tuberculosis treatment. However, rifampicin (RMP) use is associated with a 30% rate of acute graft rejection (AGR) and a 20% rate of transplant loss.

OBJECTIVE: To determine treatment outcomes in SOT recipients with active TB.

DESIGN: A retrospective study of clinical and microbiological data and TB treatment outcomes.

RESULTS: Among the 2349 transplants assessed, active TB was detected in 31 recipients; 55% had pulmonary TB and 40% were sputum smear-positive. In 32% of the patients, TB was diagnosed 30 days after symptom onset, 77% of the patients were cured and 10% died. AGR occurred in 13%.

CONCLUSION: TB was diagnosed in <30 days. Anti-tuberculosis treatment without RMP (80% vs. 67%; P = 0.48, OR 0.5, 95%CI 0.07–3.55) and with moxifloxacin yielded higher treatment success rates and a lower risk of AGR.
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Keywords: Mycobacterium tuberculosis; moxifloxacin; transplant rejection

Document Type: Research Article

Affiliations: 1: Department of Infectious Diseases, Fundacion Valle del Lili, Cali 2: Universidad Icesi, Cali 3: Clinical Research Center, Fundación Valle del Lili, Cali, Department of Public Health, Health Sciences Faculty, Universidad Icesi, Cali 4: Epidemiology Service, Public Health Agency of Barcelona and CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona 5: Hospital Clinic, Institut d'investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

Publication date: 01 November 2017

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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