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Free Content Management of child MDR-TB contacts across countries in the WHO European Region: a survey of current practice

The World Health Organization European Region has one of the highest rates of multidrug-resistant tuberculosis (MDR-TB) in the world, resulting in many vulnerable children being exposed each year. Evidence for preventive therapy following MDR-TB exposure is limited and current guidance is conflicting. An internet-based survey was performed to determine clinical practice in this region. Seventy-two clinicians from 25 countries participated. Practices related to screening and decision-making were highly variable. Just over half provided preventive therapy for children exposed to MDR-TB; the only characteristic associated with provision was practice within the European Union (adjusted OR 4.07, 95%CI 1.33–12.5).

Keywords: MDR-TB; chemoprophylaxis; paediatric; preventive treatment

Document Type: Research Article

Affiliations: 1: Medical Research Council Clinical Trials Unit at University College London, London, Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London 2: Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Southampton Respiratory Biomedical Research Unit, Southampton University Hospital NHS Foundation Trust, Southampton, Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK 3: Department of Paediatric Pulmonology, Children's Hospital, Ruhr University Bochum, Bochum, Germany 4: Second University Department of Paediatrics, National and Kapodistrian University of Athens School of Medicine, ‘P. & A. Kyriakou' Children's Hospital, Athens, Greece 5: Department of Paediatrics, Centre Hospitalière Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium 6: Medical Research Council Unit, The Gambia, Banjul, The Gambia, Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK 7: Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK

Publication date: July 1, 2017

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