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Free Content Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

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Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a ‘proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.
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Keywords: hair assays; isoniazid drug concentrations; paediatric TB; therapeutic drug monitoring; tuberculosis

Document Type: Research Article

Affiliations: 1: Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India, Johns Hopkins University School of Medicine, Baltimore, Maryland 2: Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India 3: University of California, San Francisco, California, USA 4: National Institute of Research in Tuberculosis, Chennai, India 5: Johns Hopkins University School of Medicine, Baltimore, Maryland

Publication date: June 1, 2016

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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