Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts
OBJECTIVE: To determine the association between exposure to a smoking tuberculosis (TB) case and latent tuberculous infection (LTBI).
METHOD: Between September 2009 and August 2012, we identified 2132 patients with drug-susceptible TB and their 2054 child household contacts. Data were collected on active and secondhand smoking status and other risk factors for infection specific to the index case, the household and the exposed contacts. Contacts underwent a tuberculin skin test (TST) to determine their tuberculous infection status at baseline, 6-month and 12-month follow-up. We estimated the association between exposure to a smoking index case and LTBI using a modified Poisson regression model.
RESULTS: The 21 children (age 15 years) exposed to smoking index TB patients were more likely to be TST-positive at baseline (RR 2.64, 95%CI 1.78–3.91), by 6 months (RR 1.91, 95%CI 1.40–2.60) and by 12 months (RR 1.48, 95%CI 1.07–2.06), than those who were not exposed. TST positivity among children at these time points did not vary with secondhand smoke exposure.
CONCLUSIONS: TB patients who smoke may be more likely to transmit infection to their contacts. Interventions designed to reduce smoking among TB patients may minimise further spread of the disease.
Document Type: Research Article
Affiliations: 1: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 2: Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA 3: Partners In Health, Boston, Massachusetts, USA 4: Brigham and Women's Hospital, Boston, Massachusetts, USA
Publication date: November 1, 2014
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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