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Home / The International Journal of Tuberculosis and Lung Disease, Volume 18, Number 8

Free Content Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population

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SETTING: Cytokines play an important role in anti-tuberculosis immune response, combined with antigen-presenting cells and lymphocytes. Immune response gene polymorphisms have been reported to be associated with tuberculosis (TB) susceptibility in some but not all studies.

OBJECTIVE: To evaluate the association of immune response genes with susceptibility to tuberculin skin test (TST) reactivity and/or TB.

DESIGN: Fourteen single nucleotide polymorphisms were genotyped in 96 individuals of the Aché, a native Paraguayan population, by allelic discrimination using real-time polymerase chain reaction. Univariate and multivariate Poisson regression were employed to assess risk genotypes.

RESULTS: A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG haplotype (PR 1.298, 95%CI 1.059–1.589) and with the IL-10 AT/CC diplotype (PR 1.181, 95% CI 1.024–1.362), and the presence of the IL-8 rs4073 T allele was associated with protection against TB (PR 0.482, 95%CI 0.273–0.851).

CONCLUSIONS: These results suggest that polymorphisms in genes associated with immune response are involved in TST reactivity and susceptibility to TB in the Aché population.

Keywords: Native Americans; anergy; infectious diseases; interleukins

Document Type: Research Article

Affiliations: 1: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil 2: Unidade de Epidemiologia e Estatística, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil 3: School of Human Evolution & Social Change, Arizona State University, Tempe, Arizona, USA

Publication date: August 1, 2014

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