Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012
DESIGN: Between January 2009 and February 2012, 119 contacts of MDR-TB patients were followed using a prospective observational study design. After MDR-TB disease was excluded, 12 months of daily FQ-based preventive treatment of MDR LTBI was provided by directly observed therapy.
RESULTS: Among the 119 infected contacts, 15 refused, while 104 began treatment for MDR LTBI. Of the 104 who initiated treatment, 93 (89%) completed treatment, while 4 contacts discontinued due to adverse effects. None of the 104 contacts who undertook MDR LTBI treatment of any duration developed MDR-TB disease; however, 3 of 15 contacts who refused and 15 unidentified contacts developed MDR-TB disease.
CONCLUSION: Providing treatment for MDR LTBI can be accomplished in a resource-limited setting, and contributed to preventing MDR-TB disease. The Chuuk TB program implemented treatment of MDR LTBI with an 89% completion rate. The MDR LTBI regimens were safe and well tolerated, and no TB cases occurred among persons treated for MDR LTBI.
Document Type: Research Article
Affiliations: 1: Division of TB Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Chuuk State TB Program, Ministry of Health, Chuuk, Federated States of Micronesia 3: Tuberculosis Control Section, San Francisco Department of Public Health, San Francisco, California, USA
Publication date: August 1, 2014
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