Skip to main content
padlock icon - secure page this page is secure

Free Content Smoking increases risk of recurrence after successful anti-tuberculosis treatment: a population-based study

Download Article:
(PDF 259.6 kb)
OBJECTIVE: To investigate whether tobacco smoking increases the risk of tuberculosis (TB) recurrence and identify factors associated with TB recurrence among adults who had successfully completed anti-tuberculosis treatment in Taipei, Taiwan.

METHODS: Recurrence was defined as a new clinical or microbiological diagnosis of TB requiring the start of a new course of treatment in a patient who had satisfactorily completed treatment for a previous TB episode. Cox proportional hazard models were used to calculate adjusted hazard ratios (aHRs) for recurrence.

RESULTS: We followed 5567 adults for recurrence after successful anti-tuberculosis treatment. The mean age was 58.5 years; 62.9% were male. Overall, 84 (1.5%) had a recurrence of TB during follow-up. The incidence of TB recurrence was 4.9 episodes/1000 person-years of follow-up. Cox proportional hazards regression showed that after controlling for other variables, the risk of TB recurrence among subjects who smoked >10 cigarettes a day was double that of never/former smokers. Other independent risk factors significantly associated with TB recurrence were homelessness (aHR 3.75, 95%CI 1.17–12.07), presence of comorbidities (aHR 2.66, 95%CI 1.22–5.79) and a positive acid-fast bacilli smear (aHR 2.27, 95%CI 1.47–3.49).

CONCLUSION: Smoking >10 cigarettes a day was significantly associated with TB recurrence. To reduce the risk of recurrence, we recommend including effective measures of smoking cessation in TB control programmes, as recommended by the World Health Organization Stop TB Strategy.
No Reference information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Taiwan; recurrence; smoking; tuberculosis

Document Type: Research Article

Affiliations: 1: Section of Infectious Diseases, Taipei City Hospital, Taipei City Government, Taipei, Taiwan 2: Department of Disease Control and Prevention, Taipei City Hospital, Taipei City Government, Taipei, Taiwan 3: Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan 4: Taipei Databank for Public Health Analysis, Taipei City Hospital, Taipei City Government, Taipei, Taiwan 5: Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan 6: Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan

Publication date: April 1, 2014

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on lung health world-wide.

    To share scientific research of immediate concern as rapidly as possible, The Union is fast-tracking the publication of certain articles from the IJTLD and publishing them on The Union website, prior to their publication in the Journal. Read fast-track articles.

    Certain IJTLD articles are also selected for translation into French, Spanish, Chinese or Russian. These are available on the Union website.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more