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Free Content Pharmacokinetics and serum concentrations of antimycobacterial drugs in adult Turkish patients

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OBJECTIVE: To document the pharmacokinetics and serum concentrations of first-line anti-tuberculosis drugs in adult Turkish patients with pulmonary tuberculosis (PTB).

DESIGN: Consenting 21 adult patients (aged 38 ± 4 years, 10 female and 11 male) with newly diagnosed active PTB participated in the study. Blood samples were collected 1, 2, 4, 6 and 24 h after simultaneous isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) and ethambutol (EMB) ingestion. Serum concentration-time profiles, maximum serum concentrations, time to achieve maximum serum concentrations, the half-life and the areas under the serum concentration-time curve for each of the four drugs were determined.

RESULTS: Wide variations in pharmacokinetic parameters were observed among patients. In respectively 8 (38%), 17 (81%), 3 (14%) and 1 (5%) patients, the maximum INH, RMP, PZA and EMB serum concentrations were below the accepted therapeutic concentrations.

CONCLUSION: Our data show that the serum concentrations of anti-tuberculosis drugs varied considerably in the study patients. Therapeutic drug monitoring is necessary to identify patients with subtherapeutic INH and RMP serum concentrations.
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Keywords: ethambutol; isoniazid; pyrazinamide; rifampicin; subtherapeutic levels

Document Type: Research Article

Affiliations: 1: Süreyyapaşa Chest Disease and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey 2: Department of Pharmacology, Acibadem University Medical School, Istanbul, Turkey 3: Department of Public Health, Acibadem University Medical School, Istanbul, Turkey 4: Kaan Medical Research Laboratory, Istanbul, Turkey

Publication date: 01 November 2013

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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