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Free Content Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication]

In this pilot study, we evaluated the Xpert® MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7–94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81–100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context.

Keywords: household contacts; index cases; spot-spot sputum samples

Document Type: Research Article

Affiliations: 1: National Institute for Medical Research, Mbeya Medical Research Programme, Mbeya, Tanzania 2: Liverpool School of Tropical Medicine, Liverpool, UK 3: Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany 4: Tuberculosis Research, Swiss Tropical and Public Health Institute, Basel, Switzerland; Ifakara Health Institute, Bagamoyo, Tanzania 5: Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany; DZIF German Centre for Infection Research, Munich, Germany 6: National Institute for Medical Research, Mbeya Medical Research Programme, Mbeya, Tanzania; Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany; DZIF German Centre for Infection Research, Munich, Germany

Publication date: November 1, 2012

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