Skip to main content
padlock icon - secure page this page is secure

Free Content The challenges of replicating the methodology between Phases I and III of the ISAAC programme

Download Article:
(PDF 254.8 kb)
BACKGROUND: The International Study of Asthma and Allergies in Childhood (ISAAC) used standardised methods to examine symptom prevalence of asthma, rhinitis and eczema in adolescents and children between Phases I and III. Centres followed essential rules to ensure comparability of methodology, examined by a centralised data centre.

METHODS: Centre reports (CRs) were compared for both phases and age groups. Methodological differences were categorised under major deviations (centres excluded), minor deviations (deviations identified in published tables) and very minor deviations (deviations not identified).

RESULTS: There were 112 CRs for adolescents and 70 for children. Six centres for adolescents and four for children had major deviations and were excluded. Minor deviations (35 for adolescents and 20 for children) were identified in the publications. Very minor deviations (92 for adolescents and 51 for children) were not identified. The odds ratios for having any differences in methodology between phases with a change in Principal Investigator were 0.80 (95%CI 0.36–1.81) for adolescents and 0.91 (95%CI 0.32–2.62) for children.

CONCLUSION: The majority of the centres replicated the ISAAC methodology to a high standard. Careful documentation of methodology using standardised tools with careful checks allows the full potential of studies such as ISAAC to be realised.
No Reference information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: ISAAC; adolescents; children; methodology; replication

Document Type: Research Article

Affiliations: 1: Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand 2: School of Population Health, The University of Auckland, Auckland, New Zealand 3: International Union Against Tuberculosis and Lung Disease, Paris, France 4: Department of Paediatric Respiratory Medicine, Hospital Centro de Referencia de Salud El Pino, University of Santiago de Chile, Santiago, Chile 5: Division of Community Health Sciences, St George's, University of London, London, UK

Publication date: May 1, 2012

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more