Tuberculosis incidence among contacts of active pulmonary tuberculosis
OBJECTIVE: To evaluate the 2-year incidence and predictors of TB among contacts who did not meet the Brazilian criteria for LTBI treatment.
DESIGN: Retrospective cohort study. Contacts aged between 12 and 15 years and those aged ≥15 years who did not meet the Brazilian criteria for LTBI treatment were enrolled in the study.
RESULTS: TB incidence was 3.2% (22/667), with an estimated TB rate of 1649 per 100000 population. Risk of TB was greater among the 349 contacts with TST ≥ 5mm (5.4%) compared to the 318 contacts with TST < 5 mm (0.9%; RR 6.04, 95%CI 1.7–20.6).
CONCLUSION: The high incidence of TB among contacts who did not meet the Brazilian criteria for LTBI treatment strongly suggests that these criteria should be reviewed. Furthermore, even among BCG-vaccinated contacts, TST induration ≥5 mm was the only variable that predicted the development of TB disease within 2years.
Document Type: Regular Paper
Affiliations: 1: Instituto de Doenças do Torax, Hospital Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 2: Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paolo, Brazil 3: Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA
Publication date: 01 February 2009
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