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Free Content Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia [Short communication]

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the −2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3–5.5).

Keywords: Africa; CCL2; Zambia; polymorphism; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands 2: St. Francis Hospital, Katete, Zambia 3: Department of Medical Microbiology, Vlietland Hospital, Schiedam, The Netherlands 4: Centre for Infectious Diseases Control, Epidemiology and Surveillance, National Institute of Public Health and the Environment, Bilthoven, The Netherlands 5: National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Publication date: December 1, 2008

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