Skip to main content

Meta- and pooled analyses of the effect of glutathione S-transferase M1 and T1 deficiency on chronic obstructive pulmonary disease

Buy Article:

$34.78 + tax (Refund Policy)

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene-environment interactions are very important. A number of studies have investigated the genotypes of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) in relation to COPD susceptibility in different populations. However, the results of individual studies have been inconsistent.

METHODS: To address the inconsistent findings in studies of the association of the polymorphism of the GSTM1 and GSTT1 genes with susceptibility to COPD, we performed a meta-analysis of the published data. We searched the Medline database for case-control studies published from 1966 to July 2008. Data were extracted and pooled, and ORs were calculated with their 95%CIs.

RESULTS: Twelve eligible studies comprising 1697 patients with COPD and 1867 controls were included in the meta-analysis. The pooled result showed that the GSTM1 deficiency was associated with risk of COPD (OR 1.46, 95%CI 1.16–1.83). Subgroup analysis supported the results in smoking and non-Asian populations, but not in Asian populations. The GSTT1 deficiency was not associated with risk of COPD.

CONCLUSIONS: The GSTM1 gene is a genetic contributor to overall COPD susceptibility in non-Asian populations, and the GSTT1 gene is not associated with COPD.

Keywords: COPD; case-control study; glutathione S-transferase; meta-analysis

Document Type: Regular Paper

Affiliations: 1: Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China 2: Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China 3: Experimental Medical Research Centre, Guangzhou Medical College, Guangzhou, Guangdong, China

Publication date: December 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content