Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi
OBJECTIVES: To compare 6-month and 12-month cohort treatment outcomes of HIV-positive TB patients and HIV-positive non-TB patients treated with ART.
DESIGN: Retrospective data collection using ART patient master cards and ART patient registers.
RESULTS: Between July and September 2005, 7905 patients started ART, 6967 with a non-TB diagnosis and 938 with a diagnosis of active TB. 6-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (77%) compared with non-TB patients (71%) (P < 0.001). Between January and March 2005, 4580 patients started ART, 4179 with a non-TB diagnosis and 401 with a diagnosis of active TB. 12-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (74%) compared with non-TB patients (66%) (P < 0.001). Other outcomes of default and transfer out were also significantly less frequent in TB compared with non-TB patients.
CONCLUSION: HIV-positive TB patients on ART in Malawi have generally good treatment outcomes, and more patients need to access this HIV treatment.
Document Type: Regular Paper
Affiliations: 1: Clinical HIV Unit, Ministry of Health, Lilongwe, Malawi 2: Clinical HIV Unit, Ministry of Health, Lilongwe, Malawi; Family Health International, Malawi Country Office, Lilongwe, Malawi; and London School of Hygiene and Tropical Medicine, London, UK 3: Taiwan Medical Mission, Mzuzu Central Hospital, Mzuzu, Malawi 4: US Centres for Disease Control and Prevention, Malawi Office, Lilongwe, Malawi 5: Lighthouse Clinic, Lilongwe, Malawi 6: Médecins sans Frontieres, Brussels, Belgium; and Thyolo District Hospital, Thyolo, Malawi 7: Ministry of Health, Lilongwe, Malawi; and Management Sciences for Health, Lilongwe, Malawi
Publication date: April 1, 2007
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