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Free Content Screening for tuberculosis in adults with advanced HIV infection prior to preventive therapy

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It is important to exclude tuberculosis prior to preventive therapy, but this can be difficult in patients with symptomatic human immunodeficiency virus (HIV) disease. Patients with clinically advanced HIV disease were screened for active tuberculosis using a symptom questionnaire, measured weight loss, chest radiography, sputum microscopy and culture prior to receiving tuberculosis preventive therapy. Tuberculosis was diagnosed in 11 of 129 patients screened. A simple screening instrument of two or more of the symptoms measured weight loss, cough, night sweats or fever, had a sensitivity of 100% and specificity of 88.1%, and positive and negative predictive values of 44% and 100%, respectively.
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Keywords: Africa; HIV infection; South Africa; diagnosis; screening; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Community Health, Cape Technikon, Cape Town, South Africa 2: Department of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa 3: Department of Medicine, University of Cape Town, Cape Town, South Africa 4: Department of Physiology, University of Stellenbosch, Cape Town, South Africa

Publication date: 01 June 2004

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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