@article {Sura:2005:0015-5497:205,
title = "Cerebral Pathology in Immunodeficient Gnotobiotic Laboratory Mice",
journal = "Folia Biologica",
parent_itemid = "infobike://isez/fb",
publishercode ="isez",
year = "2005",
volume = "53",
number = "3-4",
publication date ="2005-10-01T00:00:00",
pages = "205-208",
itemtype = "ARTICLE",
issn = "0015-5497",
eissn = "1734-9168",
url = "https://www.ingentaconnect.com/content/isez/fb/2005/00000053/f0020003/art00017",
doi = "doi:10.3409/173491605775142738",
keyword = "HEMOSIDERIN, MENINGITIS, HYDROCEPHALUS, KNOCKOUT MICE BRAIN",
author = "Sura, Piotr and Srebro, Zbigniew",
abstract = "Gnotobiotic autoimmunity prone, antigen presentation, T lymphocyte receptor gene knockout mice show cerebral pathology in the form of meningitis, venous blood statis with subarachnoid hemorrhages and massive hemosiderin deposits. A more or less severe hydrocephalus was present in all
animals examined. In all cases except the CD1-/- animals, the pineal gland was considerably reduced in mass. Only in the latter strain was a strong pineal hypertrophy in the form of a benign tumor present in ca. 50% of the animals. A possible sequence of events leading to hydrocephalus
is discussed. Endogenous vertically transmitted facultative pathogens, active in the immunocompromised animals, probably play a primary etiological role. The results show that caution is needed in planning immunobiological studies on the B10. PL and B10. PL-derived mice, and possibly other
strains not examined for possible neuropathological changes.",
}