Skip to main content
padlock icon - secure page this page is secure

Free Content Strain-specific Differences in Modulatory Effects of Morphine on Peritoneal Inflammation in Mice

Download Article:
(PDF 1,026.1 kb)
It has been previously shown that local administration of a high dose of morphine together with a proinflammatory agent has anti-inflammatory effects in several (but not all) strains of mice. In the present paper, behavioural and cellular consequences of morphine co-injection are compared between several strains of mice with zymosan-induced peritonitis. Males of C57C3H, Swiss, Balb/c, C57BL/6, and CBA strains were ip injected with Zymosan (40 mg/kg) and/or morphine at 0, 5, 10, 20 mg/kg without or with naltrexone pretreatment. Early stages of Zymosan-induced peritonitis were connected with intraperitoneal accumulation of leukocytes (mainly PMNs), pain symptoms (body writhes of strain-specific frequency: C57C3H>CBA>Swiss>>Balb/c∼C57BL/6), and sedation (significant in Swiss and Balb/c). Morphine co-injection abolished pain symptoms at all doses in every investigated strain, and restored locomotor activity or induced hyperlocomotion in a dose- and strain-specific manner. The highest dose of morphine inhibited intraperitoneal accumulation of peritoneal leukocytes (PTLs) including polymorphonuclear cells (PMNs) in all but the CBA strain of mice. Anti-inflammatory and anti-nociceptive effects of morphine were reversed in naltrexone pre-treated animals. The pre-incubation of Swiss but not CBA leukocytes with morphine inhibited cell chemotaxis towards zymosan-activated serum. In conclusion, morphine exerts various strain-specific effects on peritonitis.

19 References.

No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: 2005

More about this publication?
  • Folia biologica is an international quarterly journal that publishes papers on the broad field of experimental zoology, nuclear and chromosome research, and also ultrastructural studies. All papers are subject to peer reviews. Indexed in: ISI Master Journal List, Current Contents, Polish Scientific Journals Contents. I.F. 0.667
  • Editorial Board
  • Information for Authors
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more